Dejan Romelu Lukaku’s stunning strike in the dying moments of the 1-1 draw with Sampdoria was his fifth of the season and gave Villa Park the 3-1 victory.
Lukaku put Villa on the board as he found space on the edge of the box, slipped a cross for Romelucu Lukakovic to slot home a beautiful finish.
Villa are now unbeaten in six matches with a league win in each of their last five games.
However, the Rossoneri have lost seven of their past eight away games and will be without goalkeeper Victor Valdes for the trip to Sampdori.
The Dutchman missed Saturday’s draw with Bologna with a thigh injury and he was not expected to be fit for the visit of Roma.
Romelu is currently on a two-match ban for biting a referee, which is the first time he has been sent off in Serie A. In addition to Lovren’s goal, the midfielder was a constant threat from set pieces, netting twice in his team’s opening goal.
It was a promising start for Villa, who had scored just twice in their previous seven matches and the first three goals in their last six league outings.
“We are disappointed to lose the game but we are determined to try to play in the league,” Villa manager Stefano Pioli said.
“We know we will have to play with more intensity tomorrow.
We did well to create some chances in the first half but we did not score and we had to defend well.
“The team is happy with the result.
Pioli made some changes in the game, especially in the final third and we are happy with our performance.